Rosetrees researcher profile: Dr. Pascale V Guillot, UCL

Who Rosetrees Trust is funding
Dr. Pascale V Guillot’s research is about a rare disease called brittle bone disease, also known as osteogenesis imperfecta (OI). OI affects around 10,000 births and in average 70 babies per year in the UK. It inflicts painful bone fractures which start to occur in the womb and continue throughout a person’s lifetime, as well as a deformed skeleton and reduced height. There is currently no cure for this condition.

Dr. Pascale V Guillot

The Guillot lab aims to improve the quality of life of people with OI by developing innovative therapeutics to strengthen the bones, and therefore reduce the number of fractures.

“Our team is passionate about improving the quality of life of children with unbreakable spirit but suffering from bone fragility by developing the next generation of therapeutics.”

How Rosetrees Trust have supported Dr. Guillot
Dr. Guillot is a Rosetrees Trust-funded Associate Professor at University College London (UCL) who has received funding from Rosetrees Trust for two projects, starting in 2014. She has also started her third grant with Rosetrees Trust funding.

What the outcomes are of Rosetrees Trust-funded research from Dr. Guillot
The Guillot lab has found that transplantation of stem cells counteracts the fragility of the bones by secreting factors that stimulate the bone-forming cells to produce bone of better quality. These findings have a significant economic and social impact, not only for the treatment of people with OI, but also for those suffering from osteoporosis.

Dr. Guillot has recently been awarded a 3-year £870,000 grant from the MRC using her Rosetrees Trust-funded findings.

Written by: Dr. Rebecca Downing and Dr. Pascale V Guillot